1) Neurons of the innermost layer of the retina, the internal plexiform layer. They are of variable sizes and shapes, and their axons project via the optic nerve to the brain. A small subset of these cells act as photoreceptors with projections to the suprachiasmatic nucleus, the center for regulating circadian rhythm.

2) Cells of the innermost nuclear layer of the retina, the ganglion cell layer, which project axons through the optic nerve to the brain.