Home >  Term: allelic variant of unknown significance
allelic variant of unknown significance

1) An alteration in the normal sequence of a gene, the significance of which is unclear until further study of the genotype and corresponding phenotype in a sufficiently large population; complete gene sequencing often identifies numerous (sometimes hundreds) allelic variants for a given gene.

2) A variation in a genetic sequence whose association with disease risk is unknown. Also called variant of uncertain significance, unclassified variant, and VUS.

0 0

Kūrėjas

  • Max Bryant
  •  (Silver) 765 points
  • 100% positive feedback
© 2024 CSOFT International, Ltd.