Making changes to an HIV treatment regimen to make medication adherence easier. Simplifying a regimen can include reducing the number of antiretroviral (ARV) drugs in a regimen or changing to a drug that offers once-daily dosing. Other changes can include switching to ARV drugs that cause fewer adverse effects or to ARV drugs that can be taken without food. Regimen simplification can improve a person’s quality of life, help maintain long-term adherence, help prevent toxicities that may develop with long-term drug use, and reduce the risk of treatment failure.