- Industry: Library & information science
- Number of terms: 152252
- Number of blossaries: 0
- Company Profile:
The National Library of Medicine (NLM), on the campus of the National Institutes of Health in Bethesda, Maryland, is the world's largest medical library. The Library collects materials and provides information and research services in all areas of biomedicine and health care.
1) Clinical symptom complex characterized by presence of multiple cysts on the ovaries, oligomenorrhea or amenorrhea, anovulation and regularly associated with excessive amounts of body hair (hirsuitism), excessive body weight, infertility and insulin resistance.
2) A variable disorder that is marked especially by amenorrhea, hirsutism, obesity, infertility, and ovarian enlargement and is usually initiated by an elevated level of luteinizing hormone, androgen, or estrogen which results in an abnormal cycle of gonadotropin release by the pituitary gland -- abbreviation PCOS; called also polycystic ovarian disease, polycystic ovarian syndrome, polycystic ovary disease, Stein-Leventhal syndrome.
Industry:Health care
1) Coding sequence of DNA present in mature messenger RNA; DNA initially transcribed to messenger RNA consists of coding sequences (exons) and non-coding sequences (introns). Introns are spliced out of the messenger RNA prior to translation, leaving only the exons to ultimately encode the amino acid product.
2) The protein-coding DNA sequence of a gene.
3) An exon is the portion of a gene that codes for amino acids. In the cells of plants and animals, most gene sequences are broken up by one or more DNA sequences called introns. The parts of the gene sequence that are expressed in the protein are called exons, because they are expressed, while the parts of the gene sequence that are not expressed in the protein are called introns, because they come in between--or interfere with--the exons.
Industry:Health care
1) Comparative genomic hybridization (CGH) is a technique that allows the detection of losses and gains in DNA copy number across the entire genome without prior knowledge of specific chromosomal abnormalities. Comparative genomic hybridization utilizes the hybridization of differentially labeled tumor and reference DNA to generate a map of DNA copy number changes in tumor genomes. Comparative genomic hybridization is an ideal tool for analyzing chromosomal imbalances in archived tumor material and for examining possible correlations between these findings and tumor phenotypes.
2) Technique which produces a map of DNA sequence copy number as a function of chromosomal location throughout the entire genetic genome, and allows the detection of genetic deletions, duplications, and amplifications.
Industry:Health care
1) Components of the extracellular matrix consisting primarily of fibrillin. They are essential for the integrity of elastic fibers.
2) Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.
Industry:Health care
1) Compound consisting of three molecules of fatty acid esterified to glycerol; a neutral fat synthesized from carbohydrates for storage in animal adipose cells.
2) Fats composed of three fatty acid chains linked to a glycerol molecule.
Industry:Health care
1) Compound consisting of three molecules of fatty acid esterified to glycerol; a neutral fat synthesized from carbohydrates for storage in animal adipose cells.
2) Fats composed of three fatty acid chains linked to a glycerol molecule.
Industry:Health care
1) Compounds that interact with androgen receptors in target tissues to bring about the effects similar to those of testosterone. Depending on the target tissues, androgenic effects can be on sexual differentiation; male reproductive organs, spermatogenesis; secondary male sex characteristics; libido; development of muscle mass, strength, and power.
2) A family of hormones that promote the development and maintenance of male sex characteristics.
Industry:Health care
1) Condition in which bowel movements are infrequent or incomplete.
2) Decrease in normal frequency of defecation accompanied by difficult or incomplete passage of stool and/or passage of excessively hard, dry stool.
3) Constipation; irregular and infrequent or difficult evacuation of the bowels.
Industry:Health care
1) Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
2) Any of various congenital defects (as anencephaly and spina bifida) caused by incomplete closure of the neural tube during the early stages of embryonic development.
Industry:Health care
1) Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junctions.
2) An area of contact between adjacent cells characterized by modification of the plasma membranes for intercellular communication or transfer of low molecular-weight substances.
Industry:Health care
