- Industry: Library & information science
- Number of terms: 152252
- Number of blossaries: 0
- Company Profile:
The National Library of Medicine (NLM), on the campus of the National Institutes of Health in Bethesda, Maryland, is the world's largest medical library. The Library collects materials and provides information and research services in all areas of biomedicine and health care.
A type of mutation scanning in which a segment of DNA is screened for mismatch pairing between normal and mutated base pairs.
Industry:Health care
Identification of mutations by electrophoresis of double-stranded DNA samples through a denaturing gradient, such as urea. Certain mutations affect the migration pattern by changing the point in the gel at which the DNA denatures; mutant sequences can be distinguished from wild-type sequences by comparing the electrophoretic pattern.
Industry:Health care
Referring to lymphocytes, a type of white blood cell. Also refers to tissue in which lymphocytes develop.
Industry:Health care
At a particular locus heterozygous for a deleterious mutant allele and a normal allele, a deletion or other mutational event within the normal allele renders the cell either hemizygous (one deleterious allele and one deleted allele) or homozygous for the deleterious allele.
Industry:Health care
The presence of additional microsatellite alleles (repeated segments) in tumor cells, resulting from the inherent susceptibility of these areas to such alterations and from mutations in the DNA mismatch repair mechanism that would normally correct these errors.
Industry:Health care
Pertaining to, derived from, or manifesting certain features of the bone marrow. In some cases also pertains to certain types of non-lymphocyte white blood cells found in the bone marrow, including granulocyte, monocyte, and platelet lineages. Also called myelogenous.
Industry:Health care
Pertaining to, derived from, or manifesting certain features of the bone marrow. In some cases also pertains to certain types of non-lymphocyte white blood cells found in the bone marrow, including granulocyte, monocyte, and platelet lineages. Also called myelogenous.
Industry:Health care
The likelihood that an individual with a positive test result actually has the particular gene in question, is affected, or will develop the disease.
Industry:Health care
Means of identifying the shortened (truncated) proteins that result from mutations which specifically cause premature termination of mRNA translation.
Industry:Health care
A process utilizing gel electrophoresis to identify a segment of DNA containing a mutation; can be used as the first step in mutation scanning.
Industry:Health care
